Why is it that little has changed how one researches and evaluates health care despite all the health policy reforms, clinical practice innovations, increasing intersectoral interdependencies, and new medical and information technologies? These changes call out for new ways of being appraised and studied. And research approaches to clinical practice innovation cry out for being reinvented too. The 2022 World Carers Conversation, convened on Thursday, 19 May 2022, will showcase cutting-edge caregiving research, practice, and policy that will impact the world. This event will be hosted by the National Alliance for Caregiving and is made possible through the support of EuroCarers.