What is Major beta thalassemia? | Aspira Pathlab & Diagnostics | Pathology lab in Ghatkopar

Major beta thalassemia occurs when both (two) beta chain genes are deleted, resulting in the most severe form of beta thalassemia. Patients with thalassemia major need lifelong blood transfusions, continuous monitoring for complications, and therapy for iron excess (from chronic blood transfusions). The child with thalassemia may be pale, fussy, have a poor appetite, and be prone to infections throughout the first 1 to 2 years of life. Without treatment, the spleen, liver, and heart become enlarged, and bones can become thin and brittle. Iron buildup in the heart and other organs is a severe issue, leading to heart failure in some people in their teens or early twenties. Fortunately, the treatment for thalassemia has improved greatly and outcomes are improved.
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